Description

The Proxcys industrial line columns are state-of-the-art process columns with integrated lifting systems (Tripod). They combine large column volume with ease and safe handling during cleaning and maintenance. With the Tripod frame, different sections of the column can be opened and closed on the spot, without any manual labor, nor a roof mounted hoist. Decreasing downtime and risk, whilst improving safety. These Tripod columns feature an integrated lifting system, certified for pharmaceutical production.

  • Tripod Lifting systems for safe maintenance and inspection
  • Time efficient, decreasing down-time and risk whilst improving safety.
  • Product yield ≥ conventional processing methods
  • Small footprint, easy handling ( 150L-12cm - 1m² - 1000kg)
  • Full audit package: FAT, SAT, IQOQ
  • Fully automated operation (Pack, Run, Unpack, CIP)
  • Reduced buffer usage
Properties
Bed volume30 – 2500 L
Bed heights6, 12, 20 cm
Custom BH6 – 30 cm
MaterialsSS (316L, 904L)
FrameCastors or levelling feet
SS frit GP9, 10µm, GP15, 40µm, 100µm

Proxcys Tripod columns
(Dis)Assembly, replacement of O-rings and maintenance and inspection, is highly facilitated by the integrated Tripod lifting system that enables the column to be opened at place without external facility hoist equipment.

Opening and closing of the column and the annular Packing Port is controlled via a small wired handheld controller (HMI), attached to the column.
The Proxcys Tripod System Design is considered to be the benchmark for clean-room compatible mechanics, as the design combines cleanroom compatibility with accuracy, reliability, risk reducing by manual handling and optimal operator friendliness.

Tripod_positions
Tripod chromatogtaphy column

The images show multiple column positions:

  • 1. Gel clearing / Cleaning inspection
  • 2. Inner filter removal (maintenance)
  • 3. Outer filter removal (maintenance)
  • 4. Body removal (maintenance)

These examples are for impression purposes only and do not reflect all tripod functions.


Maintenance and Service
With the Tripod frame, different sections of the column can be opened and closed on the spot, without any manual labor, nor a roof mounted hoist.
Decreasing downtime and risk, whilst improving safety. Also, the Packing port is integrated in the Tripod frame, meaning the Packing port is operated by the Tripod as well.

Even the tallest Tripod columns can be operated and serviced in relatively small clean-rooms of less than 3m net ceiling height! This will offer significantly reduced operating cost from reduction in energy consumption and improved environmental sustainability. Proxcys Radial Flow Chromatography columns are linear scalable from lab-scale to industrial scale, up to 1200L and higher.

Proxcys Tripod columns in the field


In the last years, Proxcys has installed many Tripod columns paired with Proxcys Packing stations (ES-Pack-Q80) for the commercial fractionation of plasma proteins and vaccine manufacturing.

The ES-Pack-Q80LT is a versatile pumping system suitable for column packing and multi-purpose pumping needs. The system features a Quattroflow 5050 pump for low pulsation and gentle packing. Operation via touch screen with dedicated, intuitive Proxcys Companion™ software for flow and pressure regulated column packing and effortless, reproducible column packing.  

More information about our columns or packing stations? Please fill in the form below.

CS1203M 30L Radial FLow column with ES-Pack-Q80 packing system.
CS1203M 30L column with ES-Pack-Q80 Packing system for fully automated column packing


RFC columns footprint

Proxcys columns are linear scalable from lab-scale to industrial size. The image on the left shows an overview of the 12cm column series, from 30L to 165L.

When increasing to larger column volumes, the footprint of the column remains exactly the same, only the height will increase. This ensures that even columns with a volume of >200L, can still be rolled in and out of the clean room.

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