High Performance Radial Flow Chromatography (HP-RFC) is an efficient, low pressure technology for bio-molecule fractionation. Radial columns excel in throughput and performance at short bed-height, making HP-RFC exceptional suitable for various industrial applications.

HP-RFC technology proves to be exceptionally suitable for the following applications:

Biopharmaceutical application:(recombinant proteins)

Insulin
Interleukins
Monoclonal Antibodies
Vaccine conjugates
VLP

Functional food protein:

Lactoferrin
Globulins
Patatine
Pea-proteins
Legumes, meat replacers

Crude Feed Processing:

Monoclonal Antibody (mAb)
HEK
SF9
Homogenates
Single cell cultures

Human plasma fractionation:

Gamma globulins
Clotting factors
Wound healing
Serine proteases

HP-RFC technology has a proven track record of robustness, performance and ease of use at biopharmaceutical applications for more than fifteen years.

The technology was primary deployed in the Human blood plasma fractionation industry for the extraction of life saving medication at lowest operating cost at a large scale of production. Now, the technology has found its way into the large scale purification of monoclonal Antibodies for efficient cancer therapy on one side of the spectrum. On the other side, purified functional food proteins provide for a better health and sustainable habitation of our planet. The enormous scalability of our technology, the economic advantage and robustness of HP-RFC are key to this success.
Proxcys has successfully demonstrated applications with the world’s smallest (2ml) and largest (600L) High Performance Radial Flow Chromatography columns.
Unique to the Proxcys columns is the superior column packing control, that is fundamental to the scalability and broad application of the technology.

Radial Flow Chromatography is mainly suitable in combination with adsorptive chromatographic techniques:

Ion Exchange Chromatography
Affinity Chromatography
Hydrophobic Interaction Chromatography
Protein A / G
BioSMB

Proxcys is proud to have built a large international customer base. Proxcys understands the challenges of the pharmaceutical industry and is preferred supplier for the world’s largest fractionators. Proxcys tailor made, state-of-the-art equipment-solutions are applied at the manufacturing of e.g. Factor VIII, IX, IVIg, Fibrinogen, Plasminogen, C1-esterase inhibitor, Albumin, removal of Isoagglutinin, virus and many more.

‘Industry’s largest are already using Radial Flow Chromatography in process.‘