Proxcys B.V. is the world's primary producer of high performance low pressure cGMP compliant radial chromatography equipment

Micro RFC

Micro RFC columns: chromatographic performance of the radial column format in analytical scale volumes. Since the Micro RFC columns are an accurate scale-down...

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Lab HP-RFC

Lab HP-RFC columns offer “Radical” Chromatographic performance on bench scale. Ultra fast processing in robust processes with any resin and easy handling. Lab columns' suitability...
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SUPR columns

Extended range Micro to Process RFC columns in a prepacked-prevalidated format "plug-and-produce". Prepacked columns can be used for extended periods, dedicated projects...
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Pilot Process Industrial RFC

Proxcys High-Performance Radial Flow Chromatography (HP-RFC) columns are applicable from Pilot to Industrial scale operations. The "work-horses"...

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Accessories & Systems

Proxcys offers a full range of cGMP compliant accessories including sanitary Bubble traps, Intelligent packing systems and miscellaneous...
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Custom Engineering

Proxcys will develop and supply ancillary equipment that support your Downstream Processing tasks and handling. Sophisticated 3D modelling will allow fast turnaround...
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Product Overview

Segment Radial Columns - for method development, pilot and validation studies

Micro RFC cut

 

Micro RFC
  • "Axial style" Radial Segment Columns and Akta compatibility
  • Hydro-dynamic flow, frit style and pressure drop are similar to full radial columns
  • Accurate predictions of performance up to process scale volumes
  • Ideal scale-down model for Virus clearance studies
  • Available Prepacked & Prevalidated with any resin of choice
  • Bed heights available from 6 up to 30 cm
  • Volumes from 5 ml up to 25 ml
  • Typical flow rates: 1 - 10 ml/min

 

MD61

 

MD Method Development
  • "Slice-style" Radial Segment Columns for bench scale processing
  • Method Development scale down columns for packing and running
  • Accurate predictions up to industrial scale volumes
  • Bed Heights available from 6 up to 30 cm
  • Volumes range from 50 ml up to 1 liter
  • Typical flow-rates: 10 - 500 ml/min

 

 

MP Mini Process
  • "Industrial-style" Bench-top Radial Segment Columns
  • Mini Process (MP) columns  feature a close mimic of packing & process parameters
  • Final proof of process for the larger bed-height, industrial scale process columns
  • Bed heights available from 12 to 30 cm
  • Volumes from 1 liter up to 50 liter
  • Typical flow-rates: 100 ml/min - 20 L/min

 

High Performance Radial Columns - Lab, Pilot, Process - Industrial scale

 

mini245

Lab HP-RFC
  • Smallest High Perfromance Radial Flow Columns
  • HP-RFC columns for stand-alone high velocity processing or scale-up.
  • Bed heigts available between 3 cm and 10 cm with volumes from 75 ml to 3500 ml
  • Sanitary design columns manufactured from POM (Acetal)
  • Optionally available USP-class VI certification for Pharmaceutical production.
  • Typical flow rates: 25 ml/min - 12 L/min

 

Pilot HP-RFC
  • Pilot High Performance Radial Columns
  • cGMP cpompliant HP-RFC columns for Pharmaceutical production.
  • Bed heigts between 5 cm and 12 cm with volumes from 2L to 100L
  • Manually operated Annular packing port, contained packing
  • Sanitary design columns manufactured from PMMA (Acrylic) or stainless steel
  • Standard with USP-class VI and 3.1.B certification for Pharmaceutical production
  • Typical flow rates: 0.5 L/min - 200 L/min

 

Process HP-RFC
  • Process High Performance Radial Flow Columns
  • cGMP cpompliant HP-RFC columns for Pharmaceutical production.
  • Bed heigts between 10 cm and 20 cm with volumes from 10L to 350L
  • Automated Annular packing port, contained packing
  • Sanitary design columns manufactured from PMMA (Acrylic) or Stainless Steel
  • Standard with USP-class VI or 3.1.B certification for Pharmaceutical production
  • Typical flow rates: 3 L/min - 500 L/min

 

TRIPOD TRIO

Industrial HP-RFC
  • Industrial High Performance Radial Flow Columns
  • Compact light-weight Industrial scale Radial columns with smallest possible footprint
  • Bed heigts between 15 cm and 30 cm with volumes from 40L up to 1200L
  • Automated reproducible Annular packing
  • Stainless Steel, optionally available in light weight USP Class VI plastic
  • Typical flow rates: 10L/min - 1000 L/min

 

Disposable Columns - single use and multi use columns

 

Prepacked Prevalidated SUPR columns
  • SUPR: Single Use Prep* Radial columns  (*Pilot, *Process)
  • High Performance Annular port packed columns for a wide variety of applications
  • Pre-Packed, Pre-Conditioned and Pre-Validated with a resin of choice
  • Ideally suited for Personalized Medicine platform technology
  • "Plug and Process" for project and campaign processing
  • Bed heights between 3 and 20 cm with bed volumes from 50 ml up to 375 liter !!
  • Typical flow rates: 10 ml/min - 1000 L/min

 

Equipment  

 

LQ80 compact skid
Packing Stations
  • Dedicated compact Packing Stations for (semi)-automated packing of Annular port Radial columns
  • Packing pump optimized for reproducible packing
  • Quattroflow-diaphragm pump
  • Integrated packing port driver, optionally available in "unatteded" packing automation
  • cGMP compliant, 21CFR compliant Companion software 

 

 

 Quattroflow 150

 

 Quattroflow Four Piston Diaphragm Pumps
  • Minimal Maintenance
  • Minimal Downtime
  • Low pulsation
  • Superior containment
  • Variable flow
  • No particle shedding
  • High purity
  • Quiet operation
  • CIP& SIP

 

Bubble Traps
  • Bubble traps are avalable in multiple sizes
  • Basic configuration stainless steel frame bottom & top Acrylic tube
  • USP Class VI certified plastics
  • Electro polished Stainless steel
  • Optionally with true-CIP accessory ports

 

Accessories

 

Accessories
  • Packing control pressure Gauges
  • Column Protector
  • Certified elastomers (O-rings)
  • CPC couplings
  • Torque screwdriver
  • And many more....

 

Custom Solutions

 

 

Resin Conditioning Vessels
  • Resin washing and conditioning vessel
  • Minimal sheer by multi-directional liquid entry
  • Low frequency efficient stirring paddle
  • Resin evacuation in a highly concentrated slurry for further processing
  • Connected in-line or off-line.

 

PAT3 2017
Pack & Run
  • Packing and running workstation
  • Proxcys Companion software
  • Automated packing, manual control packing & running
  • High capacity pumping system
  • Continuous data logging of UV, pH, Conductivity, Pressure and Flow
  • GMP, 21.CFR.11 compliant

Proxcys B.V. is the world's primary producer of high performance low pressure cGMP compliant radial chromatography equipment.

Contact

Proxcys BV

Bedrijvenweg 4

NL-7833 JH Nieuw-Amsterdam

The Netherlands

Phone: +31 591 677 447

Fax: +31 591 677 448

Email: info@proxcys.com