Proxcys B.V. is the world's primary producer of high performance low pressure cGMP compliant radial chromatography equipment

Micro RFC

Micro RFC columns: chromatographic performance of the radial column format in analytical scale volumes. Since the Micro RFC columns are an accurate scale-down...

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Lab HP-RFC

Lab HP-RFC columns offer “Radical” Chromatographic performance on bench scale. Ultra fast processing in robust processes with any resin and easy handling. Lab columns' suitability...
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SUPR columns

Extended range Micro to Process RFC columns in a prepacked-prevalidated format "plug-and-produce". Prepacked columns can be used for extended periods, dedicated projects...
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Pilot Process Industrial RFC

Proxcys High-Performance Radial Flow Chromatography (HP-RFC) columns are applicable from Pilot to Industrial scale operations. The "work-horses"...

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Accessories & Systems

Proxcys offers a full range of cGMP compliant accessories including sanitary Bubble traps, Intelligent packing systems and miscellaneous...
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Custom Engineering

Proxcys will develop and supply ancillary equipment that support your Downstream Processing tasks and handling. Sophisticated 3D modelling will allow fast turnaround...
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Introduction to Radial Flow Chromatography

Radial Flow Chromatography (RFC) is an efficient, low pressure technology for bio-molecule fractionation. Thanks to the column geometry, RFC is very suitable for high throughput adsorptive separations in process, pilot or lab scale.  The short bed height, packed bed, allows robust adsorptive separations from crude feed (large dirt tolerance).

 

Comparison Axial to Radial Columns

Traditional Axial columns with a short bed height are very inefficient in space and weight demand at larger scale. To reduce column width traditional columns mostly operate at maximized bed heights, exceeding 20cm. This causes throughput to be lower, extended process duration and higher operating pressure. Often packing a "pancake-like" large volume column can be a time consuming challenge.

 

Fig. 1: Axial process column

Fig. 2: Axial column flow pathway.

 

Radial column processing features a dramatic reduction of footprint. Packing a HP-RFC column even with the shortest bed height is very straightforward. Increasing column volume does not influence packing performance since packing is linearly scalable too.

 

Fig. 3: Radial Column

Fig. 4: Radial column flow pathway.

 

Transition from Axial to Radial is essentially folding a horizontal bed into a vertical cylinder changing mainly the direction of the flow from vertical to horizontal. Bed height and chromatographic properties remain, while footprint and weight reduce dramatically. An animation of the virtual process is shown in the above video.

 

 

Summary of benefits at radial processing:

  • Faster chromatography (lower ∆P)
  • Compact high performance columns
  • Wide variety of applications
  • Compatible with all resins
  • Linear scaleable
  • Easy process transfer axial to radial using LV.
  • Highest throughput per m2.

 

Official Distributor of QUATTROFLOW

 

Proxcys is official QUATTROFLOW distributor for the BeNeLux. Quattroflow pumps, made in Germany (part of the globally operating PSG), are renowned for their outstanding performance, low shear, stability and low-pulse operation.

Proxcys B.V. is the world's primary producer of high performance low pressure cGMP compliant radial chromatography equipment.

Contact

Proxcys BV

Bedrijvenweg 4

NL-7833 JH Nieuw-Amsterdam

The Netherlands

Phone: +31 591 677 447

Fax: +31 591 677 448

Email: info@proxcys.com