Proxcys B.V. is the world's primary producer of high performance low pressure cGMP compliant radial chromatography equipment

Micro RFC

Micro RFC columns: chromatographic performance of the radial column format in analytical scale volumes. Since the Micro RFC columns are an accurate scale-down...

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Lab HP-RFC

Lab HP-RFC columns offer “Radical” Chromatographic performance on bench scale. Ultra fast processing in robust processes with any resin and easy handling. Lab columns' suitability...
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SUPR columns

Extended range Micro to Process RFC columns in a prepacked-prevalidated format "plug-and-produce". Prepacked columns can be used for extended periods, dedicated projects...
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Pilot Process Industrial RFC

Proxcys High-Performance Radial Flow Chromatography (HP-RFC) columns are applicable from Pilot to Industrial scale operations. The "work-horses"...

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Accessories & Systems

Proxcys offers a full range of cGMP compliant accessories including sanitary Bubble traps, Intelligent packing systems and miscellaneous...
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Custom Engineering

Proxcys will develop and supply ancillary equipment that support your Downstream Processing tasks and handling. Sophisticated 3D modelling will allow fast turnaround...
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Dynamic Capacity

Velocity profile: larger surface area and volume of resin at outside of column = lower velocity at outside of column = improved mass transfer at outside of column = increased dynamic capacity at outside of column.

 

The velocity profile below shows lower LV at inlet side (left) increasing proportionally to higher LV at column exit.

 

The green line would be the axial alternative column. Top X-axis shows the actual volume distribution. The intersection between axial and radial is calculated. The surface area between the blue and green line below the green line (at column entrance) is the dynamic capacity gain, the area above is dynamic capacity loss.

 

Would the RFC column express a larger dynamic capacity at breakthrough experiements? No. The capacity gain at the entrance is partially negatively compensated by the loss at the inner volume. So there is no capacity gain? Incorrect!!!  

 

Calculating the added capacity gain at given bed protrusion the transition position of 80% saturation in radial lies at lesser bed protrusion (lower bed volume).

 

Since most applications will saturate up to a calculated saturation of 80% (referring to axial column saturation profile), radial column will achieve this 80% saturation at 10-20% lower bed volume, thus at about 65-70% of the radial column packed bed volume. In other words one could increase the load or the processing speed without risk of loss of product.

 

So do we have a capacity gain at radial columns.? Yes, we can only not show this gain by breakthrough curves.

 

 

So it wouldn't be interesting to look at radial when we saturate 100%.? WRONG, Review column cost, footprint.

Official Distributor of QUATTROFLOW

 

Proxcys is official QUATTROFLOW distributor for the BeNeLux. Quattroflow pumps, made in Germany (part of the globally operating PSG), are renowned for their outstanding performance, low shear, stability and low-pulse operation.

Proxcys B.V. is the world's primary producer of high performance low pressure cGMP compliant radial chromatography equipment.

Contact

Proxcys BV

Bedrijvenweg 4

NL-7833 JH Nieuw-Amsterdam

The Netherlands

Phone: +31 591 677 447

Fax: +31 591 677 448

Email: info@proxcys.com