Proxcys B.V. is the world's primary producer of high performance low pressure cGMP compliant radial chromatography equipment

Micro RFC

Micro RFC columns: chromatographic performance of the radial column format in analytical scale volumes. Since the Micro RFC columns are an accurate scale-down...

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Lab HP-RFC columns offer “Radical” Chromatographic performance on bench scale. Ultra fast processing in robust processes with any resin and easy handling. Lab columns' suitability...
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SUPR columns

Extended range Micro to Process RFC columns in a prepacked-prevalidated format "plug-and-produce". Prepacked columns can be used for extended periods, dedicated projects...
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Pilot Process Industrial RFC

Proxcys High-Performance Radial Flow Chromatography (HP-RFC) columns are applicable from Pilot to Industrial scale operations. The "work-horses"...

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Accessories & Systems

Proxcys offers a full range of cGMP compliant accessories including sanitary Bubble traps, Intelligent packing systems and miscellaneous...
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Custom Engineering

Proxcys will develop and supply ancillary equipment that support your Downstream Processing tasks and handling. Sophisticated 3D modelling will allow fast turnaround...
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Isocratic Sanitary Packing & Running system


A packing system offers controlled packing of the column yet the equipment could also be used to condition the resin and create the performance evaluation data at the packing location. The system could even be interesting to be used for simple processing steps.


Supplementary demands

  • Accurate shear-less packing pump
  • Simple system layout
  • Robust intuitive MANUAL process control
  • Continuous UV-, pH-, Conductivity-, Pressure- and Flow- reading
  • RAW data to be protected from manipulation (21.CFR.11)
  • Small footprint
  • Low cost!


System Description


  • ES-Pack PAT20    0-20 l/min
  • ES-Pack PAT3      0-3 l/min


The velocity of the pumps is manually regulated but automatically corrected by feed-back of the accurate MAG flow meter. 3 modes of operation:

  • Manual (dial) flow setting, regulated by flow rate reading and feed back.
  • Manual (dial) flow setting not regulated (in case of air or WFI)
  • Purge setting where manual selector valve will allow a short pulse at high or low flowrate (preset to ~80% and ~40% fixed).



Specification Description Info
Pump: Quattroflow 1200 0-20 l/min
  Quattroflow 150 0-3 l/min
Note: Facilitated pump-head exchange to prevent cross contamination  
  Other pumps will become available  
Valves: 4x inlet sanitary diaphragm valves pneumatic controlled Hold pressure 6 BarG
  4x outlet sanitary diaphragm valves pneumatic controlled Hold pressure 6 BarG
Detectors: pH Proxcys cell
  Conductivity JUMO cell
  UV Knauer 280nm
  Flow-rate MAG flow meter <+/- 0.5%
  Pressure (digital) -1 to 9 BarG
Column: 1x Any column
Misc: Bubble trap with manual  vent Proxcys
Selector valve 4-way manual solvent selector valve for "Packing" or "Running"  
Packing control: Automated packing termination by pressure limit  
Control: Manual  
Data collection: Digital chart recorder 6 channels continuous monitoring Endress Hauer
Data transfer: Ethernet, USB, Flash memory card storing weeks of data  
Power fail protection: Over pressure detection will halt pump  
Logic: Incomplete flowpath will halt pump  
Column protection: Optional filter will protect column from residual resin contamination  
Footprint: 60 x 60cm  


First systems installed early 2011.

Proxcys B.V. is the world's primary producer of high performance low pressure cGMP compliant radial chromatography equipment.


Proxcys BV

Bedrijvenweg 4

NL-7833 JH Nieuw-Amsterdam

The Netherlands

Phone: +31 591 677 447

Fax: +31 591 677 448