Proxcys B.V. is the world's primary producer of high performance low pressure cGMP compliant radial chromatography equipment

Micro RFC

Micro RFC columns: chromatographic performance of the radial column format in analytical scale volumes. Since the Micro RFC columns are an accurate scale-down...

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Lab HP-RFC

Lab HP-RFC columns offer “Radical” Chromatographic performance on bench scale. Ultra fast processing in robust processes with any resin and easy handling. Lab columns' suitability...
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SUPR columns

Extended range Micro to Process RFC columns in a prepacked-prevalidated format "plug-and-produce". Prepacked columns can be used for extended periods, dedicated projects...
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Pilot Process Industrial RFC

Proxcys High-Performance Radial Flow Chromatography (HP-RFC) columns are applicable from Pilot to Industrial scale operations. The "work-horses"...

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Accessories & Systems

Proxcys offers a full range of cGMP compliant accessories including sanitary Bubble traps, Intelligent packing systems and miscellaneous...
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Custom Engineering

Proxcys will develop and supply ancillary equipment that support your Downstream Processing tasks and handling. Sophisticated 3D modelling will allow fast turnaround...
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How to transfer Axial process to Radial

Residence time is a popular parameter in transferring processes. In fact this is only valid when the bed height of the column remains the same or very similar.

 

Since Radial columns offer a stable low bed-height bed at large bed volumes, with Radial one can combine increased productivity, resin cost saving and increased product yield. Processes often run more than proportionally faster because the pressure buildup is more than proportionally less in radial columns.

 

Therefore translate residence time into (average) LV and try running a bit faster than that.

 

This transfer is done by using the reference area value which is provided with each radial column.The reference area is a imaginary cylinder (blue) which represents the corrected average surface area between the outer (2) and inner (1) boundaries Proxcys indicates the reference area in the type number of Pilot and Process HP-RFC columns e.g. CA 602 = 6cm bed height with a reference surface area of 0,2m2. Hence this column will have a flow of 200L/hr at 100cm/hr.

 

Axial:

Processing velocity expressed in LV

  • Residence time / surface area
  • Normalize to cm/hr

Radial:

Axial LV projected on Radial reference area

  • Correct for reduced pressure drop
  • Correct for increased loading efficacy

Fig. 6: From axial to radial

 

Differences in favour of Radial processing (optimizing to lower bed height)

  • Pressure drop 20-50% reduced
  • Loading efficacy improved
  • Complex feed handling improved
  • Binding kinetics (dynamic capacity)
  • Process robustness (larger process tolerance window)
  • Higher Throughput

Official Distributor of QUATTROFLOW

 

Proxcys is official QUATTROFLOW distributor for the BeNeLux. Quattroflow pumps, made in Germany (part of the globally operating PSG), are renowned for their outstanding performance, low shear, stability and low-pulse operation.

Proxcys B.V. is the world's primary producer of high performance low pressure cGMP compliant radial chromatography equipment.

Contact

Proxcys BV

Bedrijvenweg 4

NL-7833 JH Nieuw-Amsterdam

The Netherlands

Phone: +31 591 677 447

Fax: +31 591 677 448

Email: info@proxcys.com